Mgr. Jitka PRACHAŘOVÁ, Ph.D.
Telefon:
585634169
E-mail:
Pracoviště:
Katedra biofyziky
Org. jednotka:
Přírodovědecká fakulta
Adresa:
Šlechtitelů 27 - objekt 49 (C)
Místnost:
Pracovní zařazení:
Odborný asistent
ČLÁNEK
Berecka M., Prachařová J., Margiotta N., Barbanente A., Ditaranto N., Kašpárková J., Brabec V.
Platinum(IV) oxaliplatin analog containing axial benzoate ligands induces mitochondrial hyperpolarization and caspase-dependent apoptosis in pancreatic cancer cell models.
CHEMICO-BIOLOGICAL INTERACTIONS.
2026.
Ferraro G., Prachařová J., Gotte G., Massai L., Berecka M., Štarha P., Messori L., Merlino A.
Cytotoxicity and Binding to DNA, Lysozyme, Ribonuclease A, and Human Serum Albumin of the Diiodido Analog of Picoplatin.
INORGANIC CHEMISTRY.
2025.
Andršová P., Prachařová J., Novohradský V., Šterbinská S., Štarha P., Kašpárková J., Brabec V.
Phototoxicity of half-sandwich rhodium(III) complexes with anthracene and biphenyl substituents toward mammalian cancer cells and multicellular tumor spheroids.
JOURNAL OF MEDICINAL CHEMISTRY.
2025.
Prachařová J., Cyříková T., Berecka M., Biersack B., Kašpárková J., Brabec V.
Antimetastatic activity of (arene)ruthenium(II) complex of 4-aryl-4H-naphthopyran.
CHEMICO-BIOLOGICAL INTERACTIONS.
2024.
Hernández-García A., Marková L., Santana MD., Prachařová J., Bautista D., Kostrhunová H., Novohradský V., Brabec V., Ruiz J., Kašpárková J.
Cyclometalated Benzimidazole Osmium(II) Complexes with Antiproliferative Activity in Cancer Cells Disrupt Calcium Homeostasis.
INORGANIC CHEMISTRY.
2023.
Prachařová J., Kostrhunová H., Barbanente A., Margiotta N., Brabec V.
The mechanism of antiproliferative activity of the oxaliplatin pyrophosphate derivative involves its binding to nuclear DNA in cancer cells.
JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY.
2023.
Crlíková H., Kostrhunová H., Prachařová J., Kozsup M., Nagy S., Buglyó P., Brabec V., Kašpárková J.
Antiproliferative, DNA binding, and cleavage properties of dinuclear Co(III) complexes containing the bioactive quinizarin ligand.
JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY.
2020.
Song H., Allison S., Brabec V., Prachařová J.
Glycoconjugated Metallohelices have Improved Nuclear Delivery and Suppress Tumour Growth In Vivo.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION.
2020.
Novohradský V., Prachařová J., Kašpárková J.
Induction of immunogenic cell death in cancer cells by a photoactivated platinum(iv) prodrug.
Inorganic Chemistry Frontiers.
2020.
Litecká M., Prachařová J., Kašpárková J., Brabec V.
Low-dimensional compounds containing bioactive ligands. Part XV: Antiproliferative activity of tris(5-nitro-8-quinolinolato)gallium(III) complex with noticeable selectivity against the cancerous cells.
POLYHEDRON.
2020.
Hrabina O., Malina J., Kostrhunová H., Novohradský V., Prachařová J.
Optically Pure Metallohelices That Accumulate in Cell Nuclei, Condense/Aggregate DNA, and Inhibit Activities of DNA Processing Enzymes.
INORGANIC CHEMISTRY.
2020.
Hreusová M., Nováková O., Kostrhunová H., Prachařová J., Brabec V., Kašpárková J.
DNA modification by cisplatin-like Pt(II) complexes containing 1,1′-binaphtyl-2,2′-diamine ligand does not correlate with their antiproliferative activity in cancer cells.
INORGANICA CHIMICA ACTA.
2019.
Novohradský V., Vigueras G., Prachařová J.
Molecular superoxide radical photogeneration in cancer cells by dipyridophenazine iridium(III) complexes.
Inorganic Chemistry Frontiers.
2019.
Prachařová J., Vigueras G., Novohradský V., Cutillas N., Janiak C., Kostrhunová H., Kašpárková J., Ruiz J., Brabec V.
Exploring the effect of polypyridyl ligands on the anticancer activity of phosphorescent iridium(III) complexes: From proteosynthesis inhibitors to photodynamic therapy agents.
CHEMISTRY-A EUROPEAN JOURNAL.
2018.
Prachařová J., Novohradský V., Kostrhunová H., Štarha P., Trávníček Z., Kašpárková J., Brabec V.
Half-sandwich Os(ii) and Ru(ii) bathophenanthroline complexes: anticancer drug candidates with unusual potency and a cellular activity profile in highly invasive triple-negative breast cancer cells.
DALTON TRANSACTIONS.
2018.
Prachařová J., Intini F., Natile G., Kašpárková J., Brabec V.
Potentiation of cytotoxic action of cis-[PtCl2(NH3)(1M7AI)] by UVA irradiation. Mechanistic insights.
INORGANICA CHIMICA ACTA.
2018.
Kašpárková J., Kostrhunová H., Novohradský V., Prachařová J., Curci A., Margiotta N., Natile G., Brabec V.
Anticancer kiteplatin pyrophosphate derivatives show unexpected target selectivity for DNA.
Dalton Transactions (print).
2017.
Novohradský V., Zanellato I., Marzano C., Prachařová J., Kašpárková J., Gibson D., Gandin V., Osella D., Brabec V.
Epigenetic and antitumor effects of platinum (IV)-octanoato conjugates.
Scientific Reports.
2017.
Perfahl S., Bodtke A., Prachařová J., Kašpárková J., Brabec V., Cuadrado J., Sturup S., Schulzke C., Bednarski PJ.
Preparation of bis(5-phenyltetrazolato) Pt(II) and Pt(IV) analogues of transplatin and in vitro evaluation for antitumor activity.
Inorganica Chimica Acta.
2017.
Prachařová J., Radošová Muchová T., Dvořák Tomaštíková E., Intini F., Pacifico C., Natile G., Kašpárková J., Brabec V.
Anticancer potential of a photoactivated transplatin derivative containing the methylazaindole ligand mediated by ROS generation and DNA cleavage.
Dalton Transactions (print).
2016.
Brabec V., Prachařová J., Štěpánková J., Sadler P., Kašpárková J.
Photo-induced DNA cleavage and cytotoxicity of a ruthenium(II) arene anticancer complex.
Journal of Inorganic Biochemistry.
2016.
Prachařová J., Saltarella .., Radošová Muchová T., Scintilla S., Novohradský V., Nováková O., Intini FP., Pacifico C., Natile G., Ilík P., Brabec V., Kašpárková J.
Novel antitumor cisplatin and transplatin derivatives containing 1-methyl-7-azaindole: Synthesis, characterization, and cellular responses.
Journal of Medicinal Chemistry.
2015.
Štarha P., Trávníček Z., Dvořák Z., Radošová Muchová T., Prachařová J., Vančo J., Kašpárková J.
Potentiating Effect of UVA Irradiation on Anticancer Activity of Carboplatin Derivatives Involving 7-Azaindoles.
PLoS One.
2015.
Brabec V., Prachařová J., Nováková O., Gibson D., Kašpárková J.
The induction of lysis in lysogenic strains of Escherichia coli by a new antitumor transplatin derivative and its DNA interactions.
Dalton Transactions (print).
2015.
Zhao Y., Woods JA., Farrer NJ., Robinson KS., Prachařová J., Kašpárková J., Nováková O., Li H., Salassa L., Pizarro AM., Clarkson GJ., Song L., Brabec V., Sadler PJ.
Diazido mixed-amine platinum(IV) anticancer complexes activatable by visible-light form novel DNA adducts.
Chemistry: A European Journal.
2013.
Muchová T., Prachařová J., Štarha P., Olivová R., Vrána O., Benešová B., Kašpárková J., Trávníček Z., Brabec V.
Insight into the toxic effects of cis-dichloridoplatinum(II) complexes containing 7-azaindole halogeno derivatives in tumor cells.
Journal of Biological Inorganic Chemistry.
2013.
Prachařová J., Nováková O., Kašpárková J., Gibson D., Brabec V.
Toxicity in tumor cells, DNA binding mode, and resistance to decomposition by sulfur nucleophiles of new dinuclear bifunctional trans-PtII complexes containing long alkane linkers.
Pure and Applied Chemistry.
2013.
Prachařová J., Zerzánková L., Štěpánková J., Nováková O., Farrer NJ., Sadler PJ., Brabec V., Kašpárková J.
Interactions of DNA with a new platinum(IV) azide dipyridine complex activated by UVA and visible light: Relationship to toxicity in tumor cells.
Chemical Research in Toxicology.
2012.
ABSTRAKT
Brabec V., Prachařová J., Kašpárková J., Sadler PJ.
Interactions of DNA with a New Platinum(IV) Azide Dipyridine Complex Activated by UVA and Visible Light: Relationship to Toxicity in Tumor Cells.
Journal of Biological Inorganic Chemistry.
2014.
Uživatel nepovolil zobrazení dat v Portále UP.