Mgr. Lucie RÁROVÁ, Ph.D.

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585634698

Katedra experimentální biologie

Přírodovědecká fakulta

Šlechtitelů 27 A (hlavní budova)

3.24

Vědecký pracovník / Vědecko pedagogický

ČLÁNEK
Ostruszka R., Halili A., Pluháček T., Rárová L., Jirák D., Šišková K. Advanced Protein-Embedded Bimetallic Nanocomposite Optimized for In Vivo Fluorescence and Magnetic Resonance Bimodal Imaging. JOURNAL OF COLLOID AND INTERFACE SCIENCE. 2024.
Kovačević S., Banjac MK., Podunavac-Kuzmanović S., Rárová L. Local QSAR modeling of cytotoxic activity of newly designed androstane 3-oximes towards malignant melanoma cells. JOURNAL OF MOLECULAR STRUCTURE. 2023.
Bildziukevich U., Šlouf M., Rárová L. Nano-assembly of cytotoxic amides of moronic and morolic acid. Soft Matter. 2023.
Voňka P., Rárová L., Bazgier V., Berka K., Kvasnica M., Oklešťková J., Strnad M., Hrstka R. Small change – big consequence: The impact of C15-C16 double bond in a D‑ring of estrone on estrogen receptor activity. JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY. 2023.
Tomkiel AM., Czajkowska-Szczykowska D., Olchowik-Grabarek E., Rárová L., Sękowski S., Morzycki JW. A Study on the Chemistry and Biological Activity of 26-Sulfur Analogs of Diosgenin: Synthesis of 26-Thiodiosgenin S-Mono- and Dioxides, and Their Alkyl Derivatives. MOLECULES. 2022.
Rárová L., Pakulski Z., Strnad M., Kvasnicová M., Štenclová T., Cmoch P. Effect of modification of betulinic acid at the C3-carbon atom of homolupane triterpenoids on the antiproliferative activity in vitro. JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY. 2022.
Bildziukevich U., Özdemir Z., Šaman D., Rárová L. Novel cytotoxic 1,10-phenanthroline–triterpenoid amphiphiles with supramolecular characteristics capable of coordinating 64Cu(II) labels. Organic and Biomolecular Chemistry. 2022.
Li Y., Rárová L., Scarpato S., Štenclová T., Strnad M. Seasonal variation of phenolic compounds in Zostera marina (Zosteraceae) from the Baltic Sea. PHYTOCHEMISTRY. 2022.
Kuczynska K., Bończak B., Rárová L., Kvasnicová M., Strnad M. Synthesis and cytotoxic activity of 1,2,3-triazoles derived from 2,3-seco-dihydrobetulin via a click chemistry approach. JOURNAL OF MOLECULAR STRUCTURE. 2022.
Wilhelm A., Bonnet SL., Twigge L., Rárová L., Štenclová T. Synthesis, characterization and cytotoxic evaluation of chalcone derivatives. JOURNAL OF MOLECULAR STRUCTURE. 2022.
Bildziukevich U., Kvasnicová M., Šaman D., Rárová L., Wimmer Z. Novel Oleanolic Acid-Tryptamine and -Fluorotryptamine Amides: From Adaptogens to Agents Targeting In Vitro Cell Apoptosis. Plants-Basel. 2021.
Diachkov M., Ferrer Pertuz K., Oklešťková J., Rárová L., Bazgier V., Kvasnica M. Synthesis and biological activity of brassinosteroid analogues with a nitrogen-containing side chain. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2021.
Özdemir Z., Bildziukevich U., Čapková M., Rárová L. Triterpenoid–PEG Ribbons Targeting Selectivity in Pharmacological Effects. Biomedicines. 2021.
Tammam MA., Rárová L., Kvasnicová M., Gonzalez G., Strnad M. Bioactive Steroids from the Red Sea Soft Coral Sinularia polydactyla. Marine Drugs. 2020.
Fabisiak A., Brzeminski P., Berkowska K., Rárová L., Marcinkowska E., Siciński RR. Design, synthesis and biological evaluation of novel 2-alkylidene 19-norcalcitriol analogs. BIOORGANIC CHEMISTRY. 2020.
Hušková Z., Steigerová J., Oklešťková J., Rárová L., Kolář Z., Strnad M. Molecular mechanisms of plant steroids and study of their interaction with nuclear receptors in prostate cancer cells. FOOD AND CHEMICAL TOXICOLOGY. 2020.
Korda A., Rárová L., Pakulski Z., Strnad M., Oklešťková J. New lupane bidesmosides exhibiting strong cytotoxic activities in vitro. BIOORGANIC CHEMISTRY. 2020.
Savić MP., Kuzminac IZ., Škorić DĐ., Rárová L. New oxygen-containing androstane derivatives: Synthesis and biological potential. JOURNAL OF CHEMICAL SCIENCES. 2020.
Shulha O., Çiçek SS., Piccolella S., Rárová L., Strnad M. Sesquiterpene lactones from Sonchus palustris L. (Asteraceae, Cichorieae). PHYTOCHEMISTRY. 2020.
Bildziukevich U., Malík M., Özdemir Z., Rárová L., Janovská L. Spermine amides of selected triterpenoid acids: dynamic supramolecular system formation influences the cytotoxicity of the drugs. Journal of Materials Chemistry B. 2020.
Michalak K., Rárová L., Kubala M., Štenclová T., Strnad M., Wicha J. Synthesis and evaluation of Na /K -ATP-ase inhibiting and cytotoxic in vitro activities of oleandrigenin and its selected 17β-(butenolidyl)- and 17β-(3-furyl)- analogues. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY. 2020.
Ozdemir Z., Rybková M., Vlk M., Šaman D., Rárová L., Wimmer Z. Synthesis and Pharmacological Effects of Diosgenin-Betulinic Acid Conjugates. MOLECULES. 2020.
Brzeminski P., Fabisiak A., Berkowska K., Rárová L. Synthesis of Gemini analogs of 19-norcalcitriol and their platinum(II) complexes. BIOORGANIC CHEMISTRY. 2020.
Seroka B., Łotowski Z., Hryniewicka A., Rárová L. Synthesis of New Cisplatin Derivatives from Bile Acids. MOLECULES. 2020.
Rárová L., Jäger AK., Gao X., Bauer R., Grúz J., Van Staden J., Strnad M. Biological activities of extract from Coleonema album in vitr. SOUTH AFRICAN JOURNAL OF BOTANY. 2019.
Bildziukevich U., Rárová L., Janovská L., Šaman D., Wimmer Z. Enhancing effect of cystamine in its amides with betulinic acid as antimicrobial and antitumor agent in vitro. STEROIDS. 2019.
Rárová L., Ncube B., Van Staden J., Fürst R., Strnad M., Grúz J. Identification of Narciclasine as an in Vitro Anti-Inflammatory Component of Cyrtanthus contractus by Correlation-Based Metabolomics. JOURNAL OF NATURAL PRODUCTS. 2019.
Pokorná A., Bobáľ P., Oravec M., Rárová L., Bobáľová J., Jampílek J. Investigation of Permeation of Theophylline through Skin Using Selected Piperazine-2,5-Diones. MOLECULES. 2019.
Michalak K., Rárová L., Kubala M., Čechová P., Strnad M., Wicha J. Synthesis and evaluation of cytotoxic and Na /K -ATP-ase inhibitory activity of selected 5 alpha-oleandrigenin derivatives. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY. 2019.
Kvasnica M., Buchtová K., Budešínský M., Béres T., Rárová L., Strnad M. Synthesis, characterization and antiproliferative activity of seco analogues of brassinosteroids. STEROIDS. 2019.
Jorda R., Řezníčková E., Kielczewska U., Bazgier V., Berka K., Rárová L. Synthesis of novel galeterone derivatives and evaluation of their in vitro activity against prostate cancer cell lines. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY. 2019.
Kielczewska U., Morzycki JW., Rárová L., Wojtkielewicz A. The synthesis of solasodine F-homo-analogues. ORGANIC & BIOMOLECULAR CHEMISTRY. 2019.
Pendota SC., Aremu AO., Slavětínská Poštová L., Rárová L., Grúz J., Doležal K., Van Staden J. Identification and characterization of potential bioactive compounds from the leaves of Leucosidea sericea. JOURNAL OF ETHNOPHARMACOLOGY. 2018.
Bildziukevich U., Rárová L., Saman D., Wimmer Z. Picolyl amides of betulinic acid as antitumor agents causing tumor cell apoptosis. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY. 2018.
Rárová L., Sedlák D., Oklešťková J., Steigerová J., Liebl J., Zahler S., Bartůněk P., Kolář Z., Kohout L., Kvasnica M., Strnad M. The novel brassinosteroid analog BR4848 inhibits angiogenesis in human endothelial cells and induces apoptosis in human cancer cells in vitro. JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY. 2018.
Özdemir Z., Bildziukevich U., Šaman D., Havlíček L., Rárová L., Janovská L., Wimmer Z. Amphiphilic derivatives of (3 beta,17 beta)-3-hydroxyandrost-5-ene-17-carboxylic acid. Steroids. 2017.
Morrogh-Bernard HC., Foitová I., Yeen Z., Wilkin P., de Martin R., Rárová L., Doležal K., Nurcahyo W., Olšanský M. Self-medication by orang-utans (Pongo pygmaeus) using bioactive properties of Dracaena cantleyi. Scientific Reports. 2017.
Eignerová B., Tichý M., Krasulová J., Kvasnica M., Rárová L., Christová R., Urban M., Bednarczyk-Cwynar B., Hajdúch M., Šarek J. Synthesis and antiproliferative properties of new hydrophilic esters of triterpenic acids. European Journal of Medicinal Chemistry. 2017.
Ramos-Enriquez MA., Vargas-Romero K., Rárová L., Strnad M., Iglesias-Arteaga MA. Synthesis and in vitro anticancer activity of 23(23 ')E-benzylidenespirostanols derived from steroid sapogenins. Steroids. 2017.
Jiroutová P., Bazgier V., Oklešťková J., Rárová L., Strnad M., Kvasnica M. Synthesis of novel aryl brassinosteroids through alkene cross-metathesis and preliminary biological study. Steroids. 2017.
Kvasnica M., Oklešťková J., Bazgier V., Rárová L., Kořínková P., Mikulík J., Buděšínský M., Béres T., Berka K., Lu Q., Russinova E., Strnad M. Design, synthesis and biological activities of new brassinosteroid analogues with a phenyl group in the side chain. Organic & Biomolecular Chemistry. 2016.
Rárová L., Steigerová J., Kvasnica M., Bartůněk P., Křížová K., Chodounská H., Kolář Z., Sedlák D., Oklešťková J., Strnad M. Structure activity relationship studies on cytotoxicity and the effects on steroid receptors of AB-functionalized cholestanes. Journal of Steroid Biochemistry and Molecular Biology. 2016.
Sidoryk K., Korda A., Rárová L., Oklešťková J., Pakulski Z., Strnad M., Cmoch P., Gwardiak K., Karczewski R. Synthesis and Cytotoxicity of 28a-Homothiolupanes and 28a-Homothiolupane Saponins. European Journal of Organic Chemistry. 2016.
Morzycki JW., Rárová L., Grúz J., Sawczuk T., Kiełczewska U., Siergiejczyk L., Wojtkielewicz A. Synthesis of Aromatic Retinoids and Curcuminoids and Evaluation of their Antiproliferative, Antiradical, and Anti-inflammatory Activities. ChemistryOpen. 2016.
Sidoryk K., Cmoch P., Rárová L., Oklešťková J., Pakulski Z., Strnad M. Synthesis of S-(28a-homobetulin-28a-yl) thiophosphate, thiophosphonate, and thiophosphinate. Phosphorus, Sulfur and Silicon and the Related Elements. 2016.
Sidoryk K., Rárová L., Oklešťková J., Pakulski Z., Strnad M., Cmoch P., Luboradzki R. Synthesis of 28a-homoselenolupanes and 28a-homoselenolupane saponins. Organic & Biomolecular Chemistry. 2016.
Oklešťková J., Rárová L., Kvasnica M., Strnad M. Brassinosteroids: synthesis and biological activities. Phytochemistry Reviews. 2015.
Nair JJ., Rárová L., Strnad M., Bastida J., van Staden J. Mechanistic Insights to the Cytotoxicity of Amaryllidaceae Alkaloids. Natural Product Communications. 2015.
Bildziukevich U., Vida N., Rárová L., Kolář M., Šaman D. Polyamine derivatives of betulinic acid and beta-sitosterol: A comparative investigation. Elsevier Science. 2015.
Ncube B., Nair JJ., Rárová L., Strnad M., Finnie JF., Van Staden J. Seasonal pharmacological properties and alkaloid content in Cyrtanthus contractus NE Br. South African Journal of Botany. 2015.
Sidoryk K., Korda A., Rárová L., Oklešťková J., Strnad M., Cmoch P., Pakulski Z., Gwardiak K., Karczewski R., Luboradzki R. Synthesis and biological activity of new homolupanes and homolupane saponins. Tetrahedron. 2015.
Kvasnica M., Oklešťková J., Bazgier V., Rárová L., Berka K., Strnad M. Biological activities of new monohydroxylated brassinosteroid analogues with a carboxylic group in the side chain. Steroids. 2014.
Nair JJ., Rárová L., Strnad M., Bastida J., Cheesman L., Van Staden J. Crinane Alkaloids of the Amaryllidaceae with Cytotoxic Effects in Human Cervical Adenocarcinoma (HeLa) Cells. Natural Product Communications. 2014.
Cmoch P., Korda A., Rárová L., Oklešťková J., Strnad M., Luboradzki R., Pakulski Z. Synthesis and structure-activity relationship study of cytotoxic lupane-type 3 beta-O-monodesmosidic saponins with an extended C-28 side chain. Tetrahedron. 2014.
Cmoch P., Korda A., Rárová L., Oklešťková J., Strnad M., Gwardiak K., Karczewski R., Pakulski Z. Synthesis of Lupane-Type Saponins Containing an Unusual alpha-D-Idopyranoside Fragment as Potent Cytotoxic Agents. European Journal of Organic Chemistry. 2014.
Nair JJ., Rárová L., Strnad M., Bastida J., van Staden J. Alkaloids from Boophone haemanthoides (Amaryllidaceae). Natural Product Communications. 2013.
Bildziukevich U., Rárová L., Šaman D., Havlíček L., Drašar P., Wimmer Z. Amides derived from heteroaromatic amines and selected steryl hemiesters. Steroids. 2013.
Kopf S., Viola K., Atanasov AG., Jarukamjorn K., Rárová L., Kretschy N., Teichmann M., Vonach C., Saiko P., Giessrigl B., Huttary N., Raab I., Krieger S., Schumacher M., Diederich M., Strnad M., de Martin R., Szekeres T., Jaeger W., Dirsch VM., Mikulits W., Grusch M., Dolznig H., Krupitza G. In vitro characterisation of the anti-intravasative properties of the marine product heteronemin. Archives of Toxicology. 2013.
Mrózek L., Coufalová L., Rárová L., Plaček L., Opatřilová R., Dohnal J., Kráľová K., Paleta O., Král V., Drašar P., Jampílek J. New polyfluorothiopropanoyloxy derivatives of 5 beta-cholan-24-oic acid designed as drug absorption modifiers. Steroids. 2013.
Coufalová L., Mrózek L., Rárová L., Plaček L., Opatřilová R., Dohnal J., Kráľová K., Paleta O., Král V., Drašar P., Jampílek J. New propanoyloxy derivatives of 5 beta-cholan-24-oic acid as drug absorption modifiers. Steroids. 2013.
Magana-Vergara NE., Rárová L., Soto-Castro D., Farfan N., Strnad M., Santillan R. Synthesis and antiproliferative activity of novel steroidal dendrimer conjugates. Steroids. 2013.
Viola K., Kopf S., Rárová L., Jarukamjorn K., Kretschy N., Teichmann M., Vonach C., Atanasov A., Giessrigl B., Huttary N., Raab I., Krieger S., Strnad M., de Martin R., Saiko P., Szekeres T., Knasmueller S., Dirsch VM., Jaeger W., Grusch M., Dolznig H., Mikulits W., Krupitza G. Xanthohumol attenuates tumour cell-mediated breaching of the lymphendothelial barrier and prevents intravasation and metastasis. Archives of Toxicology. 2013.
Maj J., Morzycki J., Rárová L., Wasilewski G., Wojtkielewicz A. A cross-metathesis approach to the synthesis of new etretinate type retinoids, ethyl retinoate and its 9Z-isomer. Tetrahedron Letters. 2012.
Unger C., Popescu R., Giessrigl B., Rárová L., Herbacek I., Seelinger M., Diaz R., Wallnoefer B., Fritzer-Szekeres M., Szekeres T., Frisch R., Doležal K., Strnad M., De Martin R., Grusch M., Kopp B., Krupitza G. An apolar extract of Critonia morifolia inhibits c-Myc, cyclin D1 Cdc25A, Cdc25B, Cdc25C and Akt and induces apoptosis. International Journal of Oncology. 2012.
Dolečková I., Rárová L., Grúz J., Vondrusová M., Strnad M., Kryštof V. Antiproliferative and antiangiogenic effects of flavone eupatorin, an active constituent of chloroform extract of Orthosiphon stamineus leaves. Fitoterapia. 2012.
Nair JJ., Rárová L., Strnad M., Bastida J., Van Staden J. Apoptosis-inducing effects of distichamine and narciprimine, rare alkaloids of the plant family Amaryllidaceae. Bioorganic & Medicinal Chemistry Letters. 2012.
Rárová L., Zahler S., Liebl J., Kryštof V., Sedlák D., Bartůněk P., Kohout L., Strnad M. Brassinosteroids inhibit in vitro angiogenesis in human endothelial cells. Steroids. 2012.
Steigerová J., Rárová L., Oklešťková J., Křížová K., Levková M., Šváchová M., Kolář Z., Strnad M. Mechanisms of natural brassinosteroid-induced apoptosis of prostate cancer cells. Food and Chemical Toxicology. 2012.
Vida N., Svobodová H., Rárová L., Drašar P., Šaman D., Cvačka J., Wimmer Z. Polyamine conjugates of stigmasterol. Steroids. 2012.
Perez-Diaz JOH., Rárová L., Munoz Ocampo JP., Magana-Vergara NE., Farfan N., Strnad M., Santillan R. Synthesis and biological activity of 23-ethylidene-26-hydroxy-22-oxocholestane derivatives from spirostanic sapogenins. European Journal of Medicinal Chemistry. 2012.
Kvasnica M., Rárová L., Oklešťková J., Buděšínský M., Kohout L. Synthesis and cytotoxic activities of estrone and estradiol cis-dichloroplatinum(II) complexes. Bioorganic & Medicinal Chemistry. 2012.
Mrózek L., Dvořáková L., Mandelová Z., RÁROVÁ L., Řezáčová A., Plaček L., Opatřilová R., Dohnal J., Paleta O., Král V., Drašar P., Jampílek J. Investigation of new acyloxy derivatives of cholic acid and their esters as drug absorption modifiers. Steroids. 2011.
Maj J., Morzycki J., RÁROVÁ L., OKLEŠŤKOVÁ J., STRNAD M., Wojtkielewicz A. Synthesis and Biological Activity of 22-Deoxo-23-oxa Analogues of Saponin OSW-1. Journal of Medicinal Chemistry. 2011.
KRYŠTOF V., RÁROVÁ L., Liebl J., Zahler S., JORDA R., VOLLER J., CANKAŘ P. The selective P-TEFb inhibitor CAN508 targets angiogenesis. European Journal of Medicinal Chemistry. 2011.
Steigerová J., Oklešťková J., Levková M., Rárová L., Kolář Z., Strnad M. Brassinosteroids cause cell cycle arrest and apoptosis of human breast cancer cells. Chemico-Biological Interactions. 2010.
PŘÍSPĚVEK VE SBORNÍKU
STEIGEROVÁ J., RÁROVÁ L., KŘÍŽOVÁ K., OKLEŠŤKOVÁ J., ŠVÁCHOVÁ M., KOLÁŘ Z., STRNAD M. Jaderné receptory pro steroidní hormony u buněčných linií odvozených od karcinomu prsu a prostaty po ovlivnění deriváty rostlinných hormonů. In Svoboda M. (Eds.) Edukační sborník XXXVI. Brněnské onkologické dny a XXVI. Konference pro nelékařské zdravotnické pracovníky. 2012.
KAPITOLA V KNIZE
Oklešťková J., Rárová L., Strnad M. Brassinosteroids and their Biological Activities. Natural Products. 2013.
RÁROVÁ L., OKLEŠŤKOVÁ J., STEIGEROVÁ J., Kohout L., KOLÁŘ Z., STRNAD M. Anticancer Activities of Brassinosteroids. Brassinosteroids: Practical Applications in Agriculture and Human Health. 2012.
PATENT, UŽITNÝ VZOR, PRŮMYSLOVÝ VZOR
Gucký T., Jorda R., Zatloukal M., Kryštof V., Rárová L., Řezníčková E., Mikulits W., Strnad M. 2-substituted-6-biarylmethylamino-9-cyclopentyl-9H-purine derivatives, use thereof as medicaments, and pharmaceutical compositions. 2017.
Gucký T., Jorda R., Zatloukal M., Kryštof V., Rárová L., Řezníčková E., Mikulits W., Strnad M. 2-substituted-6-biarylmethylamino-9-cyclopentyl-9H-purine derivatives, use thereof as medicaments, and pharmaceutical compositions. 2016.
Gucký T., Jorda R., Zatloukal M., Kryštof V., Rárová L., Řezníčková E., Strnad M., Mikulits W. 2-substituted-6-biarylmethylamino-9-cyclopentyl-9H-purine derivatives, use thereof as medicaments, and pharmaceutical compositions. 2016.
Strnad M., Mikulits W., Gucký T., Jorda R., Zatloukal M., Kryštof V., Rárová L., Řezníčková E. 2-substituted-6-biarylmethylamino-9-cyclopentyl-9H-purine derivatives, use thereof as medicaments, and pharmaceutical compositions. 2016.
Gucký T., Jorda R., Zatloukal M., Kryštof V., Rárová L., Řezníčková E., Mikulits W., Strnad M. 2-substituted-6-biarylmethylamino-9-cyclopentyl-9H-purine derivatives, use thereof as medicaments, and pharmaceutical compositions. 2016.
Morzycki JW., Wojtkielewicz A., Oklešťková J., Hoffmannová L., Strnad M. Novel saponin compounds, methods of preparation thereof, use thereof and pharmaceutical compositions. 2015.
Morzycki J., Wojtkielewicz A., Oklešťková J., Hoffmannová L., Strnad M. Novel saponin compounds, methods of preparation thereof, use thereof and pharmaceutical compositions. 2014.
Morzycki J., Wojtkielewicz A., Oklešťková J., Hoffmannová L., Strnad M. Novel saponin compounds, methods of preparation thereof, use thereof and pharmaceutical compositions. 2014.
Morzycki J., Wojtkielewitz A., Strnad M., Rárová L., Oklešťková J. Novel saponin compounds, methods of preparation thereof, use thereof and pharmaceutical compositions. 2013.
Morzycki J., Wojtkielewicz A., Oklešťková J., Rárová L., Strnad M. Saponin compounds, methods of preparation thereof, use thereof and pharmaceutical compositions. 2013.
Morzycki J., Wojtielewicz A., Oklešťková J., Hoffmannová L., Strnad M. Novel saponin compounds, methods of preparation thereof, use thereof and pharmaceutical compositions. 2012.
Kohout L., Chodounská H., Hniličková J., Kasal A., Černý I., Kolář Z., Strnad M., Oklešťková J., Steigerová J., Hoffmannová L. Použití cholestanových derivátů k výrobě léčiva pro léčbu nádorového bujení a s ním spojené angiogeneze. 2012.
ABSTRAKT
Křížová K., Steigerová J., Rárová L., Oklešťková J., Šváchová M., Kolář Z., Strnad M. Účinek cholestanových derivátů na buněčné linie. Edukační sborník Brněnské onkologické dny. 2011.

Uživatel nepovolil zobrazení dat v Portále UP.

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