2022

Barghash RF, Eldehna WM, Kovalová M, Vojáčková V, Kryštof V, Abdel-Aziz HA. One-pot three-component synthesis of novel pyrazolo[3,4-b]pyridines as potent anti-leukemia agents. Eur. J. Med. Chem. 227C, 113952, 2022. doi: 10.1016/j.ejmech.2021.113952

Bertrand J, Dostálová H, Kryštof V, Jorda R, Delgado T, Castro-Alvarez A, Mella J, Cabezas D, Faúndez M, Espinosa-Bustos C, Salas CO. Design, Synthesis, In Silico Studies and Inhibitory Activity towards Bcr-Abl, BTK and FLT3-ITD of New 2,6,9-Trisubstituted Purine Derivatives as Potential Agents for the Treatment of Leukaemia. Pharmaceutics. 2022; 14(6):1294. doi: 10.3390/pharmaceutics14061294

Colak N, Kurt-Celebi A, Gruz J, Strnad M, Hayirlioglu-Ayaz S, Choung MG, Esatbeyoglu T, Ayaz FA. The Phenolics and Antioxidant Properties of Black and Purple versus White Eggplant Cultivars. Molecules. 2022 Apr 8;27(8):2410. doi: 10.3390/molecules27082410

Cüce M, Colak N, Ćavar Zeljković S, Tarkowski P, Strnad M, Gruz J, Vehbi İmamoğlu K, Ayaz FA. An evaluation of volatiles and phenolic compounds in conjunction with the antioxidant capacity of endemic endangered species of Erodium hendrikii Alpınar. South African Journal of Botany. 2022; 149:458-467. doi: 10.1016/j.sajb.2022.06.010

Fortuna A, Gonçalves-Pereira R, Costa PJ, Jorda R, Vojáčková V, Gonzalez G, Heise NV, Csuk R, Oliveira MC, Xavier NM. Synthesis and Exploitation of the Biological Profile of Novel Guanidino Xylofuranose Derivatives. ChemMedChem. 2022 May 16;e202200180. doi: 10.1002/cmdc.202200180

Ganai AM, Pathan TK, Merugu SR, Kozlanská K, Vojáčková V, Kryštof V, Mokoena S, Kayamba F, Karpoormath R. Development of Pyrimidine-Cinnamamide Hybrids as Potential Anticancer agents: A Rational Design Approach. J. Mol. Struct. 2022, 133594. doi: 10.1016/j.molstruc.2022.133594

Heger T, Zatloukal M, Kubala M, Strnad M, Gruz J. Procyanidin C1 from Viola odorata L. inhibits Na+,K+-ATPase. Sci Rep. 2022 Apr 29;12(1):7011. doi: 10.1038/s41598-022-11086-y

Hernychova L, Alexandri E, Tzakos AG, Zatloukalová M, Primikyri A, Gerothanassis IP, Uhrik L, Šebela M, Kopečný D, Jedinák L, Vacek J. Serum albumin as a primary non-covalent binding protein for nitro-oleic acid. Int J Biol Macromol. 2022 Jan 18:S0141-8130(22)00060-5. doi: 10.1016/j.ijbiomac.2022.01.050

Jorda R, Havlíček L, Peřina M, Vojáčková V, Pospíšil T, Djukic S, Škerlová J, Grúz J, Renešová N, Klener P, Řezáčová P, Strnad M, Kryštof V. 3,5,7-Substituted Pyrazolo[4,3-d]Pyrimidine Inhibitors of Cyclin-Dependent Kinases and Cyclin K Degraders. J Med Chem. 2022 Jun 24. doi: 10.1021/acs.jmedchem.1c02184

Klos D, Dušek M, Samol'ová E, Zatloukal M, Nožková V, Nesnas N, Plačková L, Koprna R, Spíšek Z, Vylíčilová H, Plíhal O, Doležal K, Voller J, Kadlecová A, Strnad M, Plíhalová L. New Water-Soluble Cytokinin Derivatives and Their Beneficial Impact on Barley Yield and Photosynthesis. J Agric Food Chem. 2022 Jun 6. doi: 10.1021/acs.jafc.2c00981

Kuczynska K, Bonczak B, Rarova L, Kvasnicova M, Strnad M, Pakulski Z, Cmoch P, Fialkowski M. Synthesis and cytotoxic activity of 1,2,3-triazoles derived from 2,3-seco-dihydrobetulin via a click chemistry approach. Journal of Molecular Structure. 2022; 1250, 131751. doi: 10.1016/j.molstruc.2021.131751

Li Y, Rárová L, Scarpato S, Çiçek SS, Jordheim M, Štenclová T, Strnad M, Mangoni A, Zidorn C. Seasonal variation of phenolic compounds in Zostera marina (Zosteraceae) from the Baltic Sea. Phytochemistry. 2022 Jan 19;196:113099. doi: 10.1016/j.phytochem.2022.113099

Nisler J, Pěkná Z, Končitíková R, Klimeš P, Kadlecová A, Murvanidze N, Werbrouck SPO, Plačková L, Kopečný D, Zalabák D, Spíchal L, Strnad M.  Cytokinin oxidase/dehydrogenase inhibitors: first extension - outlook for selectivity and high efficiency. J Exp Bot. 2022 May 6:erac201. doi: 10.1093/jxb/erac201

Opitz A, Seitz LM, Kryštof V, Baselious F, Holzer M, Sippl W, Hilgeroth A. Novel effective small-molecule inhibitors of protein kinases related to tau pathology in Alzheimer's disease. Future Med Chem. 2022 Aug;14(16):1175-1186. doi: 10.4155/fmc-2022-0061

Razmiene B, Vojáčková V, Řezníčková E, Malina L, Dambrauskiene V, Kubala M, Bajgar R, Kolářová H, Žukauskaite A, Arbačiauskiene E, Šačkus A, Kryštof V. Synthesis of N-aryl-2,6-diphenyl-2H-pyrazolo[4,3-c]pyridin-7-amines and their photodynamic properties in the human skin melanoma cell line G361. Bioorg Chem. 2022 Feb;119:105570. doi: 10.1016/j.bioorg.2021.105570

Supikova K, Kosinova A, Vavrusa M, Koplikova L, François A, Pospisil J, Zatloukal M, Wever R, Hartog A, Gruz J. Sulfated phenolic acids in plants. Planta. 2022 May 13;255(6):124. doi: 10.1007/s00425-022-03902-6

Toman D, Jorda R, Ajani H, Kryštof V, Cankař P. Synthesis of 4-styrylpyrazoles and evaluation of their inhibitory effects on cyclin-dependent kinases. Med Chem. 2022; 18(4):484-496. doi: 10.2174/1573406417666210806095710

Vlková K, Gucký T, Peřina M, Řezníčková E, Kryštof V. Synthesis and biological activity evaluation of novel 2,6,9-trisubstituted purine conjugates as potential protein kinases inhibitors. Bioorg Med Chem Lett. 2022 Mar 15;60:128603. doi: 10.1016/j.bmcl.2022.128603

Wilhelm A, Bonnet SL, Twigge L, Rarova L, Stenclova T, Visser HG, Schutte-Smith M. Synthesis, characterization and cytotoxic evaluation of chalcone derivatives. Journal of Molecular Structure. 2022; 1251, 132001. doi: 10.1016/j.molstruc.2021.132001

2021

Ajduković JJ, Jakimov DS, Rárová L, Strnad M, Dzichenka YU, Usanov S, Škorić DD,  Jovanović-Šanta SS, Sakač MN. Novel alkylaminoethyl derivatives of androstane 3-oximes as anticancer candidates: Synthesis and evaluation of cytotoxic effect. RSC Advances, 2021, 11, 37449 – 37461. doi: 10.1039/D1RA07613B

Bildziukevich U, Kvasnicová M, Šaman D, Rárová L, Wimmer Z: Novel oleanolic acid-tryptamine and –fluorotryptamine amides: From adaptogens to agents targeting in vitro cell apoptosis. Plants 2021, 10(10), 2082. doi: 10.3390/plants10102082

Dayal N, Řezníčková E, Hernandez DE, Peřina M, Torregrosa-Allen S, Elzey BD, Škerlová J, Ajani H, Djukic S, Vojáčková V, Lepšík M, Řezáčová P, Kryštof V, Jorda R, Sintim HO. 3H-Pyrazolo[4,3-f]quinoline-Based Kinase Inhibitors Inhibit the Proliferation of Acute Myeloid Leukemia Cells In Vivo. J Med Chem. 2021 Aug 12;64(15):10981-10996. doi: 10.1021/acs.jmedchem.1c00330.

Diachkov MV, Ferrer K, Oklestkova J, Rarova L, Bazgier V, Kvasnica M. Synthesis and Biological Activity of Brassinosteroid Analogues with a Nitrogen-Containing Side Chain. Int J Mol Sci. 2021;22(1):155. doi: 10.3390/ijms22010155

Ferrer K, Díaz K, Kvasnica M, Olea AF. Cuellar, M, Espinoza L. Synthesis of New Brassinosteroid 24-Norcholane Type Analogs Conjugated in C-3 with Benzoate Groups. Molecules 2021, 26, 1173. doi: 10.3390/molecules26041173

Florencio-Ortiz V, Grúz J, Casas JL. Changes in the free phenolic acid composition of pepper (Capsicum annuum L.) leaves in response to green peach aphid (Myzus persicae Sulzer) infestation. Arthropod-Plant Interactions 15, 329–336 (2021). doi: 10.1007/s11829-021-09820-w

Gonzalez G, Grúz J, D'Acunto CW, Kaňovský P, Strnad M. Cytokinin Plant Hormones Have Neuroprotective Activity in In Vitro Models of Parkinson's Disease. Molecules. 2021 Jan 12;26(2):361. doi: 10.3390/molecules26020361

Gonzalez G, Hodoň J, Kazakova A, D'Acunto CW, Kaňovský P, Urban M, Strnad M. Novel pentacyclic triterpenes exhibiting strong neuroprotective activity in SH-SY5Y cells in salsolinol- and glutamate-induced neurodegeneration models Eur J Med Chem. 2021 Jan 16;213:113168. doi: 10.1016/j.ejmech.2021.113168

Hemelíková N, Žukauskaitė A, Pospíšil T, Strnad M, Doležal K, Mik V. Caged Phytohormones: From Chemical Inactivation to Controlled Physiological Response. J Agric Food Chem. 2021 Oct 5. doi: 10.1021/acs.jafc.1c02018

Hendrychová D, Jorda R, Kryštof V. How selective are clinical CDK4/6 inhibitors? Med Res Rev. 2021 May;41(3):1578-1598. doi: 10.1002/med.21769

Hrdlička J, Gucký T, van Staden J, Novák O, Doležal K. A stable isotope dilution method for a highly accurate analysis of karrikins. Plant Methods. 2021 Apr 1;17(1):37.  doi: 10.1186/s13007-021-00738-1

Hlophe NP, Aremu AO, Gruz J, Van Staden J, Finnie JF. Influence of different cytokinins on the phenolic acids and antioxidant activity of two Brachystelma species. Plant Cell Tiss Organ Cult 2021, 145,689–699. doi: 10.1007/s11240-021-02038-x

Iškauskienė M, Kadlecová A, Voller J, Janovská L, Malinauskienė V, Žukauskaitė A, Šačkus A. Synthesis of 5-[(1H-indol-3-yl)methyl]-1,3,4-oxadiazole-2(3H)-thiones and their protective activity against oxidative stress. Arch Pharm (Weinheim). 2021 Mar 18;e2100001. doi: 10.1002/ardp.202100001

Jansa J, Jorda R, Škerlová J, Pachl P, Peřina M, Řezníková E, Heger, T, Gucký T, Řezáčová P, Lyčka A, Kryštof V. Imidazo[1,2‐c]pyrimidin‐5(6H)‐one inhibitors of CDK2: Synthesis, kinase inhibition and co-crystal structure. Eur J Med Chem. 2021 Apr 15;216:113309. doi: 10.1016/j.ejmech.2021.113309

Jorda R, Molitorová M, Pilařová P, Vojáčková V, Řezníčková E, Svobodová K, Pauk K, Imramovský A, Kryštof V. Pseudopeptides with aldehyde or vinylsulfone warheads: synthesis and antiproteasomal activity. Bioorg Chem. 2021 Jul 31;115:105228. doi: 10.1016/j.bioorg.2021.105228

Kiełczewska U, Jorda R, Gonzalez G, Morzycki JW, Ajani H, Svrčková K, Štěpánková Š, Wojtkielewicz A. The synthesis and cholinesterase inhibitory activities of solasodine analogues with seven-membered F ring. J Steroid Biochem Mol Biol. 2021 Jan;205:105776. doi: 10.1016/j.jsbmb.2020.105776

Kiss MA , Peřina M, Bazgier V, May  V, Baji A, Jorda R, Frank E. Synthesis of dihydrotestosterone derivatives modified in the A-ring with (hetero)arylidene, pyrazolo[1,5-a]pyrimidine and triazolo[1,5-a]pyrimidine moieties and their targeting of the androgen receptor in prostate cancer. J Steroid Biochem Mol Biol. 2021 Jul;211:105904. doi: 10.1016/j.jsbmb.2021.105904

Koprna R, Humplik JF, Spisek Z, Bryksova M, Zatloukal M, Mik V, Novak O, Nisler J, Dolezal K. Improvement of Tillering and Grain Yield by Application of Cytokinin Derivatives in Wheat and Barley. Agronomy 2021, 11(1), 67 doi: 10.3390/agronomy11010067

Krajčovičová S, Jorda R, Vanda D, Soural M, Kryštof V. 1,4,6-Trisubstituted imidazo[4,5-c]pyridines as inhibitors of Bruton's tyrosine kinase. Eur J Med Chem. 2021 Feb 5;211:113094. doi: 10.1016/j.ejmech.2020.113094

Makhaye N, Aremu AO, Gruz J, Magadlela A. Effects of soil nutrients and microbe symbiosis on the nutrient assimilation rates, growth carbon cost and phytochemicals in Mucuna pruriens (L.) DC. Acta Physiol Plant 43, 153 (2021). doi: 10.1007/s11738-021-03321-2

Maková B, Mik V, Lišková B, Gonzalez G, Vítek D, Medvedíková M, Monfort B, Ručilová V, Kadlecová A, Khirsariya P, Gándara Barreiro Z, Havlíček L, Zatloukal M, Soural M, Paruch K, D'Autréaux B, Hajdúch M, Strnad M, Voller J. Cytoprotective activities of kinetin purine isosteres. Bioorg Med Chem. 2021 Jan 6;33:115993. doi: 10.1016/j.bmc.2021.115993

Mirzaee M, Holásková E, Mičúchová A, Kopečný DJ, Osmani Z, Frébort I.  Long-Lasting Stable Expression of Human LL-37 Antimicrobial Peptide in Transgenic Barley Plants. Antibiotics (Basel). 2021 Jul 23;10(8):898. doi: 10.3390/antibiotics10080898

Morina F, Mijovilovich A, Koloniuk I, Pěnčík A, Grúz J, Novák O, Küpper H. Interactions between zinc and Phomopsis longicolla infection in the roots of Glycine max. J Exp Bot. 2021 Feb 5:erab052. doi: 10.1093/jxb/erab052

Nisler J, Kopečný D, Pěkná Z, Končitíková R, Koprna R, Murvanidze N, Werbrouck SPO, Havlíček L, De Diego N, Kopečná M, Wimmer Z, Briozzo P, Moréra S, Zalabák D, Spíchal L, Strnad M. Diphenylurea-derived cytokinin oxidase/dehydrogenase inhibitors for biotechnology and agriculture. J Exp Bot. 2021 Feb 2;72(2):355-370. doi: 10.1093/jxb/eraa437

Özdemir Z, Bildziukevich U, Čapková M, Lovecká P, Rárová L, Šaman D, Zgarbová M, Lapuníková B, Weber J, Kazakova O, Wimmer Z. Triterpenoid–peg ribbons targeting selectivity in pharmacological effects.  Biomedicines 2021, 9(8), 951. doi: 10.3390/biomedicines9080951

Özdemir Z, Šaman D, Bertula K, Lahtinen M, Bednárová L, Pazderková M, Rárová L, Nonappa, Wimmer Z. Rapid Self-Healing and Thixotropic Organogelation of Amphiphilic Oleanolic Acid-Spermine Conjugates. Langmuir. 2021 Mar 2;37(8):2693-2706. doi: 10.1021/acs.langmuir.0c03335

Razmienė B, Řezníčková E, Dambrauskienė V, Ostruszka R, Kubala M, Žukauskaitė A, Kryštof V, Šačkus A, Arbačiauskienė E. Synthesis and Antiproliferative Activity of 2,4,6,7-Tetrasubstituted-2H-pyrazolo[4,3-c]pyridines. Molecules 2021, 26(21), 6747. doi: 10.3390/molecules26216747

Rouchal M, Rudolfová J, Kryštof V, Vojáčková V, Čmelík R, Vícha R. Adamantane-substituted purines and their beta-cyclodextrin complexes: Synthesis and biological activity. Int. J. Mol. Sci. 2021, 22(23), 12675. doi: 10.3390/ijms222312675

Schade N, Koch P, Ansideri F, Krystof V, Holzer M, Hilgeroth A. Evaluation of Novel Substituted Furopyridines as Inhibitors of Protein Kinases Related to Tau Pathology in Alzheimer´s Disease. Med Chem. 2021 Jun 1; 17(8):844-855. doi: 10.2174/1573406417666210601144510

Zhang C, Žukauskaitė A, Petřík I, Pěnčík A, Hönig M, Grúz J, Široká J, Novák O, Doležal K. In situ characterisation of phytohormones from wounded Arabidopsis leaves using desorption electrospray ionisation mass spectrometry imaging. Analyst. 2021 Apr 26;146(8):2653-2663. doi: 10.1039/d0an02118k

Nahoru

2020

Antoniadi I, Novák O, Gelová Z, Johnson A, Plíhal O, Simerský R, Mik V, Vain T, Mateo-Bonmatí E, Karady M, Pernisová M, Plačková L, Opassathian K, Hejátko J, Robert S, Friml J, Doležal K, Ljung K, Turnbull C. Cell-surface receptors enable perception of extracellular cytokinins. Nat Commun. 2020 Aug 27;11(1):4284. doi: 10.1038/s41467-020-17700-9.

Bertrand J, Dostálová H, Krystof V, Jorda R, Castro A, Mella J, Espinosa-Bustos C, María Zarate A, Salas CO. New 2,6,9-trisubstituted purine derivatives as Bcr-Abl and Btk inhibitors and as promising agents against leukemia. Bioorg Chem. 2020 Jan;94:103361. doi: 10.1016/j.bioorg.2019.103361. Epub 2019 Oct 17. PMID: 31699386.

Bildziukevich U, Malík M, Özdemir Z, Rárová L, Janovská L, Šlouf M, Šaman D, Šarek J, Nonappa, Wimmer Z. Spermine amides of selected triterpenoid acids: dynamic supramolecular system formation influences the cytotoxicity of the drugs. J Mater Chem B. 2020 Jan 22;8(3):484-491. doi: 10.1039/c9tb01957

Bryksová M, Dabravolski S, Kučerová Z, Zavadil Kokáš F, Špundová M, Plíhalová L, Takáč T, Grúz J, Hudeček M, Hloušková V, Koprna R, Novák O, Strnad M, Plíhal O, Doležal K. Aromatic Cytokinin Arabinosides Promote PAMP-like Responses and Positively Regulate Leaf Longevity. ACS Chem Biol. 2020 Jul 17;15(7):1949-1963. doi: 10.1021/acschembio.0c00306. Epub 2020 Jun 29. PMID: 32520524.

Brzeminski P, Fabisiak A, Berkowska K, Rárová L, Marcinkowska E, Sicinski RR. Synthesis of Gemini analogs of 19-norcalcitriol and their platinum(II) complexes. Bioorg Chem. 2020 Jul;100:103883. doi: 10.1016/j.bioorg.2020.103883. Epub 2020 Apr 25. PMID: 32361296.

Fabisiak A, Brzeminski P, Berkowska K, Rárová L, Marcinkowska E, Sicinski RR. Design, synthesis and biological evaluation of novel 2-alkylidene 19-norcalcitriol analogs. Bioorg Chem. 2020 Aug;101:104013. doi: 10.1016/j.bioorg.2020.104013. Epub 2020 Jun 12. PMID: 32629275.

Gebashe F, Aremu AO, Gruz J, Finnie JF, Van Staden J. Phytochemical Profiles and Antioxidant Activity of Grasses Used in South African Traditional Medicine. Plants (Basel). 2020 Mar 17;9(3):371. doi: 10.3390/plants9030371. PMID: 32192145; PMCID: PMC7154885.

Grauso L, Li Y, Scarpato S, Shulha O, Rárová L, Strnad M, Teta R, Mangoni A, Zidorn C. Structure and Conformation of Zosteraphenols, Tetracyclic Diarylheptanoids from the Seagrass Zostera marina: An NMR and DFT Study. Org Lett. 2020 Jan 3;22(1):78-82. doi: 10.1021/acs.orglett.9b03964. Epub 2019 Dec 13. PMID: 31834807.

Gupta S, Hrdlička J, Ngoroyemoto N, Nemahunguni NK, Gucký T, Novák O, Kulkarni MG, Doležal K, Van Staden J. Preparation and Standardisation of Smoke-Water for Seed Germination and Plant Growth Stimulation. Journal of Plant Growth Regulation volume 39, 338–345 (2020)

Huskova Z, Steigerova J, Oklestkova J, Rarova L, Kolar Z, Strnad M. Molecular mechanisms of plant steroids and study of their interaction with nuclear receptors in prostate cancer cells. Food Chem Toxicol. 2020 Mar;137:111164. doi: 10.1016/j.fct.2020.111164. Epub 2020 Jan 27. PMID: 32001316.

Jacques F, Zhao Y, Kopečná M, Končitíková R, Kopečný D, Rippa S, Perrin Y. Roles for ALDH10 enzymes in γ-butyrobetaine synthesis, seed development, germination, and salt tolerance in Arabidopsis. J Exp Bot. 2020 Dec 31;71(22):7088-7102. doi: 10.1093/jxb/eraa394. PMID: 32845293.

Jorda R, Krajčovičová S, Králová P, Soural M, Kryštof V. Scaffold hopping of the SYK inhibitor entospletinib leads to broader targeting of the BCR signalosome. Eur J Med Chem. 2020 Oct 15;204:112636. doi: 10.1016/j.ejmech.2020.112636. Epub 2020 Jul 19. PMID: 32731189.

Jorda R, Magar P, Hendrychová D, Pauk K, Dibus M, Pilařová E, Imramovský A, Kryštof V. Novel modified leucine and phenylalanine dipeptides modulate viability and attachment of cancer cells. Eur J Med Chem. 2020 Feb 15;188:112036. doi: 10.1016/j.ejmech.2020.112036. Epub 2020 Jan 7. PMID: 31931341.

Kopecny D, Vlcko T. Plant biotechnology: Green for Good V 2019. N Biotechnol. 2020 Jul 25;57:1-3. doi: 10.1016/j.nbt.2020.01.004. Epub 2020 Feb 1. PMID: 32017997.

Köprülüoğlu C, Dejmek M, Šála M, Ajani H, Hřebabecký H, Fanfrlík J, Jorda R, Dračínský M, Procházková E, Šácha P, Kryštof V, Hobza P, Lepšík M, Nencka R. Optimization of norbornyl-based carbocyclic nucleoside analogs as cyclin-dependent kinase 2 inhibitors. J Mol Recognit. 2020 Aug;33(8):e2842. doi: 10.1002/jmr.2842. Epub 2020 Mar 25. PMID: 32212222.

Korda A, Rárová L, Pakulski Z, Strnad M, Oklešťková J, Kuczynska K, Cmoch P, Gwardiak K, Karczewski R. New lupane bidesmosides exhibiting strong cytotoxic activities in vitro. Bioorg Chem. 2020 Jul;100:103868. doi: 10.1016/j.bioorg.2020.103868. Epub 2020 Apr 27. PMID: 32388425.

Kubiasová K, Montesinos JC, Šamajová O, Nisler J, Mik V, Semerádová H, Plíhalová L, Novák O, Marhavý P, Cavallari N, Zalabák D, Berka K, Doležal K, Galuszka P, Šamaj J, Strnad M, Benková E, Plíhal O, Spíchal L. Cytokinin fluoroprobe reveals multiple sites of cytokinin perception at plasma membrane and endoplasmic reticulum. Nat Commun. 2020 Aug 27;11(1):4285. doi: 10.1038/s41467-020-17949-0

Matušková V, Zatloukal M, Voller J, Grúz J, Pěkná Z, Briestenská K, Mistríková J, Spíchal L, Doležal K, Strnad M. New aromatic 6-substituted 2'-deoxy-9-(β)-d-ribofuranosylpurine derivatives as potential plant growth regulators. Bioorg Med Chem. 2020 Jan 15;28(2):115230. doi: 10.1016/j.bmc.2019.115230. Epub 2019 Nov 29. PMID: 31862308.

Michalak K, Rárová L, Kubala M, Štenclová T, Strnad M, Wicha J. Synthesis and evaluation of Na+/K+-ATP-ase inhibiting and cytotoxic in vitro activities of oleandrigenin and its selected 17β-(butenolidyl)- and 17β-(3-furyl)- analogues. Eur J Med Chem. 2020 Sep 15;202:112520. doi: 10.1016/j.ejmech.2020.112520. Epub 2020 Jun 22. PMID: 32645647.

Milišiūnaitė V, Kadlecová A, Žukauskaitė A, Doležal K, Strnad M, Voller J, Arbačiauskienė E, Holzer W, Šačkus A. Synthesis and anthelmintic activity of benzopyrano[2,3-c]pyrazol-4(2H)-one derivatives. Mol Divers. 2020 Nov;24(4):1025-1042. doi: 10.1007/s11030-019-10010-3. Epub 2019 Nov 11. PMID: 31713185.

Oliveira DM, Mota TR, Salatta FV, Sinzker RC, Končitíková R, Kopečný D, Simister R, Silva M, Goeminne G, Morreel K, Rencoret J, Gutiérrez A, Tryfona T, Marchiosi R, Dupree P, Del Río JC, Boerjan W, McQueen-Mason SJ, Gomez LD, Ferrarese-Filho O, Dos Santos WD. Cell wall remodeling under salt stress: Insights into changes in polysaccharides, feruloylation, lignification, and phenolic metabolism in maize. Plant Cell Environ. 2020 Sep;43(9):2172-2191. doi: 10.1111/pce.13805. Epub 2020 Jul 13. PMID: 32441772.

Özdemir Z, Rybková M, Vlk M, Šaman D, Rárová L, Wimmer Z. Synthesis and Pharmacological Effects of Diosgenin-Betulinic Acid Conjugates. Molecules. 2020 Aug 3;25(15):3546. doi: 10.3390/molecules25153546. PMID: 32756514; PMCID: PMC7435711.

Said MA, Eldehna WM, Nocentini A, Fahim SH, Bonardi A, Elgazar AA, Kryštof V, Soliman DH, Abdel-Aziz HA, Gratteri P, Abou-Seri SM, Supuran CT. Sulfonamide-based ring-fused analogues for CAN508 as novel carbonic anhydrase inhibitors endowed with antitumor activity: Design, synthesis, and in vitro biological evaluation. Eur J Med Chem. 2020 Mar 1;189:112019. doi: 10.1016/j.ejmech.2019.112019. Epub 2020 Jan 2. PMID: 31972394.

Savić MP, Kuzminac IZ, Škorić DD, Jakimov DS, Rárová L, Sakač MN, Djurendić EA. New oxygen-containing androstane derivatives: Synthesis and biological potential. Journal of Chemical Sciences volume 132, Article number: 98 (2020)

Savić MP, Škorić DĐ, Kuzminac IZ, Jakimov DS, Kojić VV, Rárová L, Strnad M, Djurendić EA. New A-homo lactam D-homo lactone androstane derivative: Synthesis and evaluation of cytotoxic and anti-inflammatory activities in vitro. Steroids. 2020 May;157:108596. doi: 10.1016/j.steroids.2020.108596. Epub 2020 Feb 14. PMID: 32068078.

Seroka B, Łotowski Z, Hryniewicka A, Rárová L, R Sicinski R, M Tomkiel A, W Morzycki J. Synthesis of New Cisplatin Derivatives from Bile Acids. Molecules. 2020 Feb 4;25(3):655. doi: 10.3390/molecules25030655. PMID: 32033039; PMCID: PMC7036801.

Shulha O, Çiçek SS, Piccolella S, Rárová L, Strnad M, Sönnichsen F, Pacifico S, Zidorn C. Sesquiterpene lactones from Sonchus palustris L. (Asteraceae, Cichorieae). Phytochemistry. 2020 Feb;170:112196. doi: 10.1016/j.phytochem.2019.112196. Epub 2019 Nov 12. PMID: 31731238.

Štětková M, Growková K, Fojtík P, Valčíková B, Palušová V, Verlande A, Jorda R, Kryštof V, Hejret V, Alexiou P, Rotrekl V, Uldrijan S. CDK9 activity is critical for maintaining MDM4 overexpression in tumor cells. Cell Death Dis. 2020 Sep 15;11(9):754. doi: 10.1038/s41419-020-02971-3. PMID: 32934219; PMCID: PMC7494941.

Tammam MA, Rárová L, Kvasnicová M, Gonzalez G, Emam AM, Mahdy A, Strnad M, Ioannou E, Roussis V. Bioactive Steroids from the Red Sea Soft Coral Sinularia polydactyla. Mar Drugs. 2020 Dec 10;18(12):632. doi: 10.3390/md18120632. PMID: 33322046; PMCID: PMC7763444.

Vambe M, Aremu AO, Chukwujekwu JC, Gruz J, Luterová A, Finnie JF, Van Staden J. Antibacterial, Mutagenic Properties and Chemical Characterisation of Sugar Bush (Protea caffra Meisn.): A South African Native Shrub Species. Plants (Basel). 2020 Oct 9;9(10):1331. doi: 10.3390/plants9101331. PMID: 33050284; PMCID: PMC7600625.

Varvuolytė G., Malina L., Bieliauskas A., Hošíková B., Simerská H., Kolářová H., Kleizienė N., Kryštof V., Šačkus A., Žukauskaitė A.: Synthesis and photodynamic properties of pyrazole-indole hybrids in the human skin melanoma cell line G361. Dyes Pigment. 183C, 108666, 2020. doi: 10.1016/j.dyepig.2020.108666

 

Nahoru

Patenty

Bíbová J, Mik V, Zatloukal M, Plíhalová L, Grúz J, Spíchal L, Doležal K, Strnad M. 9-(2-oxacycloalkyl)-9H-purine-2,6-diamine derivatives, preparations containing these derivatives and their use. EP18726308.2. 15/06/2022

Varvuolyté G., Malina V, Bieliauskas A., Hošíková B., Simerská H., Kolářová H., Kleiziené N., Strnad M., Arbačiauskiené E., Kryštof V.,  Sačkus A., Zukauskaité A. Pyrazol-indolové konjugáty pro fotodynamickou léčbu rakoviny a bakteriálních infekcí. CZ 309070. 01/12/2021

Gonzalez G, Mik V, Bucharová N, Grúz J, Kaňovský P, Strnad M, Zatloukal M. Heterocyklické dusíkaté deriváty purinu, farmaceutické přípravky obsahující tyto deriváty a jejich použití při neuroprotekci. CZ 308800. 14/04/2021

Gucky T, Reznickova E, Jorda R, Krystof V, Strnad M, Radosova Muchova T, Divoky V. 2,6-Disubstituted-9-cyclopentyl-9H-purins, use thereof as medicaments, and pharmaceutical compositions. US 11028087 B2. 08/06/2021

Gucky T, Reznickova E, Jorda R, Krystof V, Strnad M, Radosova Muchova T, Divoky V. 2,6-Disubstituted-9-cyclopentyl-9H-purins, use thereof as medicaments, and pharmaceutical compositions. EP3601287. 15/12/2021

Havlíček L, Šturc A, Řezníčková E, Jorda R, Kryštof V, Strnad M. 5-Alkylthio-7-[(4-arylbenzyl)amino]-1(2)H-pyrazolo[4,3-d]pyrimidiny pro léčení lymfomů. Úřad průmyslového vlastnictví, CZ 308484. 05/08/2020.

Havlíček L, Šturc A, Řezníčková E, Jorda R, Kryštof V, Strnad M. 5-Alkylthio-7-[(4-arylbenzyl)amino]-1(2)H-pyrazolo[4,3-d]pyrimidines for treatment of lymphoma. EP 3749670. 06/10/2021

Havlíček L, Šturc A, Řezníčková E, Jorda R, Kryštof V, Strnad M. 5-Alkylthio-7-[(4-arylbenzyl)amino]-1(2)H-pyrazolo[4,3-d]pyrimidines for treatment of lymphoma. US11186583. 30/11/2021

Hönig M, Plíhalová L, Doležal K, Voller J, Strnad M, Spíchal L, Vostálová J, Rajnochová Svobodová A, Ulrichová J, Kadlecová A, Plíhal O. Adenine derivatives and their use as UV-photoprotective agents. US 10774084. 15/9/2020

Doležal K, Plíhalová L, Vylíčilová H, Zatloukal M, Plíhal O, Voller J, Strnad M, Van Staden J, Ponnusamy B, Kumari A, Aremu AO. 6-aryl-9-glykosylpurines and use thereof. US 10550144. 4/2/2020

Doležal K, Plíhalová L, Vylíčilová H, Zatloukal M, Plíhal O, Voller J, Strnad M, Bryksová M, Vostálová J, Rajnochová Svobodová A, Ulrichová J, Spíchal L. 6-aryl-9-glykosylpurines and use thereof. SG 11201704019T. 24/6/2020

Doležal K, Plíhalová L, Vylíčilová H, Zatloukal M, Plíhal O, Voller J, Strnad M, Van Staden J, Baskaran P, Kumari A, Aremu AO, 6-aryl-9-glycosylpurines and use thereof. EP 3229772. 29/4/2020

Nahoru

Nastavení cookies a ochrany soukromí

Na našich webových stránkách používáme soubory cookies a případné další síťové identifikátory, které mohou obsahovat osobní údaje (např. jak procházíte naše stránky). My a někteří poskytovatelé námi využívaných služeb, máme k těmto údajům ve Vašem zařízení přístup nebo je ukládáme. Tyto údaje nám pomáhají provozovat a zlepšovat naše služby. Pro některé účely zpracování takto získaných údajů je vyžadován Váš souhlas. Svůj souhlas můžete kdykoliv změnit nebo odvolat (odkaz najdete v patě stránek).

(Technické cookies nezbytné pro fungování stránek. Neobsahují žádné identifikační údaje.)
(Slouží ke statistickým účelům - měření a analýze návštěvnosti. Sbírají pouze anonymní data.)
(Jsou určeny pro propagační účely, měření úspěšnosti propagačních kampaní apod.)