Mgr. Aneta VRZALOVÁ, Ph.D.
Telefon:
585634910
E-mail:
Pracoviště:
Katedra buněčné biologie a genetiky
Org. jednotka:
Přírodovědecká fakulta
Adresa:
Šlechtitelů 27 - objekt 51 (E)
Místnost:
3.09
Pracovní zařazení:
odborný asistent
ČLÁNEK
Vrzalová A., Pečinková P., Illés P., Gurská S., Džubák P., Szotkowski M., Hajdúch M., Mani S., Dvořák Z.
Mixture Effects of Tryptophan Intestinal Microbial Metabolites on Aryl Hydrocarbon Receptor Activity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES.
2022.
Dvořák Z., Kopp F., Costello CM., Vrzalová A., Štěpánková M., Zůvalová I., Jiskrová E., Poulíková K., Vyhlídalová B.
Targeting the pregnane X receptor using microbial metabolite mimicry.
EMBO Molecular Medicine.
2020.
Ženata O., Vrzalová A., Bachleda P., Janečková J., Panáček A., Kvítek L., Vrzal R.
The effect of graphene oxide on signalling of xenobiotic receptors involved in biotransformation.
CHEMOSPHERE.
2020.
Vrzal R., Vrzalová A., Grycová A., Dvořák Z.
Activated thyroid hormone receptor modulates dioxin-inducible aryl hydrocarbon receptor-mediated CYP1A1 induction in human hepatocytes but not in human hepatocarcinoma HepG2 cells.
Toxicology Letters.
2017.
Dořičáková A., Theile D., Weiss J., Vrzal R.
Differential effects of the enantiomers of tamsulosin and tolterodine on P-glycoprotein and cytochrome P450 3A4.
Naunyn-Schmiedeberg's Archives of Pharmacology.
2017.
Pastorková B., Vrzalová A., Bachleda P., Dvořák Z.
Hydroxystilbenes and methoxystilbenes activate human aryl hydrocarbon receptor and induce CYP1A genes in human hepatoma cells and human hepatocytes.
Food and Chemical Toxicology.
2017.
Pasquel D., Dořičáková A., Li H., Kortagere S., Krasowski MD., Biswas A., Walton WG., Redinbo MR., Dvořák Z., Mani S.
Acetylation of Lysine 109 Modulates Pregnane X Receptor DNA Binding and Transcriptional Activity.
BBA Gene Regulatory Mechanisms.
2016.
Kubešová K., Dořičáková A., Trávníček Z., Dvořák Z.
Mixed-ligand copper(II) complexes activate aryl hydrocarbon receptor AhR and induce CYP1A genes expression in human hepatocytes and human cell lines.
Toxicology Letters.
2016.
Štěpánková M., Krasulová K., Dořičáková A., Kurka O., Anzenbacher P., Dvořák Z.
Optical isomers of dihydropyridine calcium channel blockers display enantiospecific effects on the expression and enzyme activities of human xenobiotics-metabolizing cytochromes P450.
Toxicology Letters.
2016.
Dořičáková A., Vrzal R.
A food contaminant ochratoxin A suppresses pregnane X receptor (PXR)-mediated CYP3A4 induction in primary cultures of human hepatocytes.
Toxicology.
2015.
Vrzal R., Ženata O., Dořičáková A., Dvořák Z.
Environmental pollutants parathion, paraquat and bisphenol A show distinct effects towards nuclear receptors-mediated induction of xenobiotics-metabolizing cytochromes P450 in human hepatocytes.
Toxicology Letters.
2015.
Grycová A., Dořičáková A., Dvořák Z.
Impurities contained in antifungal drug ketoconazole are potent activators of human aryl hydrocarbon receptor.
Toxicology Letters.
2015.
Korhoňová M., Dořičáková A., Dvořák Z.
Optical Isomers of Atorvastatin, Rosuvastatin and Fluvastatin Enantiospecifically Activate Pregnane X Receptor PXR and Induce CYP2A6, CYP2B6 and CYP3A4 in Human Hepatocytes.
PLoS One.
2015.
Vávrová A., Vrzal R., Dvořák Z.
A nonradioactive electrophoretic mobility shift assay for measurement of pregnane X receptor binding activity to CYP3A4 response element.
Electrophoresis.
2013.
Novotná A., Dořičáková A., Pávek P., Dvořák Z.
Construction and characterization of peroxisome proliferator-activated receptor-gamma co-activator 1 alpha (PGC-1α over-expressing cell line derived from human hepatocyte carcinoma HepG2 cells).
Biomedical Papers-Olomouc.
2013.
Dořičáková A., Novotná A., Vrzal R., Pávek P., Dvořák Z.
The role of residues T248, Y249 and T422 in the function of human pregnane X receptor.
Archives of Toxicology.
2013.
NOVOTNÁ A., DOŘIČÁKOVÁ A., VRZAL R., PÁVEK P., DVOŘÁK Z.
Construction and characterization of hepatocyte nuclear factor HNF4alpha1 over-expressing cell line derived from human hepatoma HepG2 cells.
European Journal of Pharmacology.
2011.
VRZAL R., DOŘIČÁKOVÁ A., NOVOTNÁ A., BACHLEDA P., Bitman M., PÁVEK P., DVOŘÁK Z.
Valproic acid augments vitamin D receptor-mediated induction of CYP24 by vitamin D3: A possible cause of valproic acid-induced osteomalacia.
Toxicology Letters.
2011.
Novotná A., Dořičáková A., Vrzal R., Maurel P., Pávek P., Dvořák Z.
Investigation of Orlistat effects on PXR activation and CYP3A4 expression in primary human hepatocytes and human intestinal LS174T cells.
European Journal of Pharmaceutical Sciences.
2010.
Aktuálně vyučované předměty
| název předmětu | katedra/zkratka | semestr | typ | hodin |
|---|---|---|---|---|
| Bakalářská práce 1 | KBB/BAKP1 | ZS | Cv | 0 |
| Bakalářská práce 2 | KBB/BAKP2 | LS | Cv | 0 |
| Praktikum z buněčné biologie | KBB/BBC | ZS | Cv | 8 |
| Cvičení z buněčné biologie 1 | KBB/BBCMB | ZS | Cv | 2 |
| Buněčná biologie 2 | KBB/BB2 | LS | Cv | 32 |
| Molekulární biologie 2 | KBB/MBIO2 | LS | Př | 2 |
| Moderní techniky studia buňky | KBB/MTSB | ZS | Př | 2 |
| Prakt. cv. z moder. technik studia buňky | KBB/PCMTS | ZS | Cv | 0 |