Prof. RNDr. Viktor BRABEC, DrSc.

Zástupný obrázek
Kontaktní údaje

585634154, 607824450

viktor.brabec@upol.cz

Katedra biofyziky

Přírodovědecká fakulta

Šlechtitelů 27 - objekt 49 (C)

1.13A

profesor

molekulární biofyzika a farmakologie, struktura a interakce nukleových kyselin, vztah mezi strukturou a farmakologickou aktivitou protinádorově účinných látek

ČLÁNEK
Marco A., Kašpárková J., Bautista D., Kostrhunová H., Cutillas N., Markocá L., Novohradský V., Ruiz J., Brabec V. A novel substituted benzo[g]quinoxaline-based cyclometalated Ru(II) complex as a biocompatible membrane-targeted PDT colon cancer stem cell agent. JOURNAL OF MEDICINAL CHEMISTRY. 2024.
Marco A., Kašpárková J., Bautista D., Kostrhunová H., Cutillas N., Marková L., Novohradský V., Ruiz J., Brabec V. A novel substituted benzo[g]quinoxaline-based cyclometalated Ru(II) complex as a biocompatible membrane-targeted PDT colon cancer stem cell agent. JOURNAL OF MEDICINAL CHEMISTRY. 2024.
Prachařová J., Cyříková T., Berecka M., Biersack B., Kašpárková J., Brabec V. Antimetastatic activity of (arene)ruthenium(II) complex of 4-aryl-4H-naphthopyran. CHEMICO-BIOLOGICAL INTERACTIONS. 2024.
Song H., Kostrhunová H., Červinka J., Brabec V., Rogers NJ., Scott P. Dicobalt(II) helices kill colon cancer cells via enantiomer-specific mechanisms; DNA damage or microtubule disruption. Chemical Science. 2024.
Malina J., Crowley JD., Brabec V. Interaction of dinuclear Co(III) cylinders with higher-order DNA structures. CHEMICO-BIOLOGICAL INTERACTIONS. 2024.
Marková L., Maji M., Kostrhunová H., Novohradský V., Kašpárková J., Gibson D., Brabec V. Multi-action Pt(IV) prodrugs releasing cisplatin and dasatinib are potent anticancer and anti-invasive agents displaying synergism between the two drugs. JOURNAL OF MEDICINAL CHEMISTRY. 2024.
Cervinka J., Hernández-García A., Bautista D., Markova L., Kostrhunova H., Malina J., Kašpárková J., Santana D., Brabec V., Ruiz J. New cyclometalated Ru(II) polypyridyl photosensitizers trigger oncosis in cancer cells by inducing damage to cellular membranes. Inorganic Chemistry Frontiers. 2024.
Malina J., Kostrhunová H., Brabec V. Ni(II) Cylinders Damage DNA in Cancer Cells and Preferentially Bind Y-Shaped DNA Three-Way Junctions Blocking DNA Synthesis. Small. 2024.
Kašpárková J., Novohradský V., Ruiz J., Brabec V. Photoactivatable, mitochondria targeting dppz iridium(III) complex selectively interacts and damages mitochondrial DNA in cancer cells. CHEMICO-BIOLOGICAL INTERACTIONS. 2024.
Hernández-García A., Marková L., Santana MD., Prachařová J., Bautista D., Kostrhunová H., Novohradský V., Brabec V., Ruiz J., Kašpárková J. Cyclometalated Benzimidazole Osmium(II) Complexes with Antiproliferative Activity in Cancer Cells Disrupt Calcium Homeostasis. INORGANIC CHEMISTRY. 2023.
Bresciani G., Červinka J., Kostrhunová H., Biancalana L., Bortoluzzi M., Pampaloni G., Novohradský V., Brabec V., Marchetti F., Kašpárková J. N-Indolyl diiron vinyliminium complexes exhibit antiproliferative effects in cancer cells associated with disruption of mitochondrial homeostasis, ROS scavenging, and antioxidant activity. CHEMICO-BIOLOGICAL INTERACTIONS. 2023.
Schleser SW., Krytovych O., Ziegelmeier T., Gross E., Kašpárková J., Brabec V., Weber T., Schobert R., Mueller T. Palladium and Platinum Complexes of the Antimetabolite Fludarabine with Vastly Enhanced Selectivity for Tumour over Non-Malignant Cells. MOLECULES. 2023.
Prachařová J., Kostrhunová H., Barbanente A., Margiotta N., Brabec V. The mechanism of antiproliferative activity of the oxaliplatin pyrophosphate derivative involves its binding to nuclear DNA in cancer cells. JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY. 2023.
Hreusová M., Novohradský V., Marková L., Brabec V. Gallium(III) Complex with Cloxyquin Ligands Induces Ferroptosis in Cancer Cells and Is a Potent Agent against Both Differentiated and Tumorigenic Cancer Stem Rhabdomyosarcoma Cells. BIOINORGANIC CHEMISTRY AND APPLICATIONS. 2022.
Schmidt C., Babu T., Kostrhunová H., Brabec V. Are Pt(IV) prodrugs that release combretastatin A4 true multi-action prodrugs? JOURNAL OF MEDICINAL CHEMISTRY. 2021.
Hreusová M., Brabec V., Nováková O. Processing and Bypass of a Site-Specific DNA Adduct of the Cytotoxic Platinum–Acridinylthiourea Conjugate by Polymerases Involved in DNA Repair: Biochemical and Thermodynamic Aspects. International Journal of Molecular Sciences. 2021.
Masaryk L., Nemec I., Kašpárková J., Brabec V., Štarha P. Unexpected solution behaviour of ester-functionalized half-sandwich Ru(II) and Ir(III) complexes. Dalton Transactions. 2021.
Nunhart P., Konkolova E., Janovec L., Kašpárková J., Malina J., Brabec V. Antimicrobial activity and DNA/HSA interaction of fluorinated 3,6,9-trisubstituted acridines. CHEMICAL PAPERS. 2020.
Crlíková H., Kostrhunová H., Prachařová J., Kozsup M., Nagy S., Buglyó P., Brabec V., Kašpárková J. Antiproliferative, DNA binding, and cleavage properties of dinuclear Co(III) complexes containing the bioactive quinizarin ligand. JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY. 2020.
Litecká M., Prachařová J., Kašpárková J., Brabec V. Low-dimensional compounds containing bioactive ligands. Part XV: Antiproliferative activity of tris(5-nitro-8-quinolinolato)gallium(III) complex with noticeable selectivity against the cancerous cells. POLYHEDRON. 2020.
Nagy I., Farkas ER., Kašpárková J., Kostrhunová H., Brabec V., Buglyó P. Synthesis and characterization of (Ru(II), Co(III)) heterobimetallic complexes formed with a 1,10-phenanthroline based hydroxamic acid conjugate. JOURNAL OF ORGANOMETALLIC CHEMISTRY. 2020.
Novohradský V., Marková L., Kostrhunová H., Trávníček Z., Brabec V., Kašpárková J. An anticancer Os(II) bathophenanthroline complex as a human breast cancer stem cell selective, mammosphere potent agent that kills cells by necroptosis. Scientific Reports. 2019.
Hreusová M., Nováková O., Kostrhunová H., Prachařová J., Brabec V., Kašpárková J. DNA modification by cisplatin-like Pt(II) complexes containing 1,1′-binaphtyl-2,2′-diamine ligand does not correlate with their antiproliferative activity in cancer cells. INORGANICA CHIMICA ACTA. 2019.
Janočková J., Korábečný J., Plšíková J., Kašpárková J., Brabec V. In vitro investigating of anticancer activity of new 7-MEOTA-tacrine heterodimers. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY. 2019.
Hrabina O., Brabec V., Nováková O. Translesion DNA synthesis across lesions induced by oxidative products of pyrimidines: An insight into the mechanism by microscale thermophoresis. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2019.
Chen F., Soldevila-Barreda J., Romero-Canelón I., Coverdale J., Song J., Clarkson G., Kašpárková J., Habtemariam A., Brabec V., Wolny J., Schünemann V., Sadler P. Effect of sulfonamidoethylenediamine substituents in Ru-II arene anticancer catalysts on transfer hydrogenation of coenzyme NAD( ) by formate. DALTON TRANSACTIONS. 2018.
Intini FP., Zajac J., Novohradský V., Saltarella T., Pacifico C., Brabec V., Natile G., Kašpárková J. Novel Antitumor Platinum(II) Conjugates Containing the Nonsteroidal Anti-inflammatory Agent Diclofenac: Synthesis and Dual Mechanisms of Antiproliferative Effects. Inorganic Chemistry. 2017.
Perfahl S., Bodtke A., Prachařová J., Kašpárková J., Brabec V., Cuadrado J., Sturup S., Schulzke C., Bednarski PJ. Preparation of bis(5-phenyltetrazolato) Pt(II) and Pt(IV) analogues of transplatin and in vitro evaluation for antitumor activity. Inorganica Chimica Acta. 2017.
Bečka M., Vilková M., Salem OM., Kašpárková J., Brabec V., Kožurková M. 3-[(E)-(acridin-9 '-ylmethylidene)amino]-1-substituted thioureas and their biological activity. Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy. 2017.
Janočková J., Zilecká E., Kašpárková J., Brabec V., Soukup O., Kuča K., Kožurková M. Assessment of DNA-binding affinity of cholinesterase reactivators and electrophoretic determination of their effect on topoisomerase I and II activity. Molecular BioSystems. 2016.
Muenzer J., Biersack B., Albrecht A., Rehm T., Lacher U., Milius W., Casini A., Zhang J., Ott I., Brabec V., Stuchlíková O., Andronachte I., Schuppan D., Kaps L., Schobert R. Ferrocenyl-Coupled N-Heterocyclic Carbene Complexes of Gold(I): A Successful Approach to Multinuclear Anticancer Drugs. Chemistry: A European Journal. 2016.
Yellol J., Perez S., Yellol G., Zajac J., Donaire A., Novohradský V., Janiak C., Brabec V., Ruiz J. Highly potent extranuclear-targeted luminescent iridium(III) antitumor agents containing benzimidazole-based ligands with a handle for functionalization. Chemical Communications. 2016.
Malina J., Hannon M., Brabec V. Iron(II) supramolecular helicates interfere with the HIV-1 Tat-TAR RNA interaction critical for viral replication. Scientific Reports. 2016.
Salem OM., Vilková M., Janočková J., Jendželovský R., Fedoročko P., Zilecká E., Kašpárková J., Brabec V., Imrich J., Kožurková M. New spiro tria(thia)zolidine-acridines as topoisomerase inhibitors, DNA binders and cytostatic compounds. International Journal of Biological Macromolecules. 2016.
Kašpárková J., Kostrhunová H., Nováková O., Křikavová R., Vančo J., Trávníček Z., Brabec V. A Photoactivatable Platinum(IV) Complex Targeting Genomic DNA and Histone Deacetylases. Angewandte Chemie - International Edition. 2015.
Janočková .., Plšíková J., Kašpárková J., Brabec V., Jendželovský R., Mikeš J., Koval J., Hamuľ áková S., Fedoročko P., Kuča K., Kožurková M. Inhibition of DNA topoisomerases I and II and growth inhibition of HL-60 cells by novel acridine-based compounds. European Journal of Pharmaceutical Sciences. 2015.
Prachařová J., Saltarella .., Radošová Muchová T., Scintilla S., Novohradský V., Nováková O., Intini FP., Pacifico C., Natile G., Ilík P., Brabec V., Kašpárková J. Novel antitumor cisplatin and transplatin derivatives containing 1-methyl-7-azaindole: Synthesis, characterization, and cellular responses. Journal of Medicinal Chemistry. 2015.
Novohradský V., Zhe L., Vojtíšková M., Sadler PJ., Brabec V., Kašpárková J. Mechanism of cellular accumulation of an iridium(III) pentamethylcyclopentadienyl anticancer complex containing a C,N-chelating ligand. Metallomics. 2014.
Frýbortová M., Nováková O., Brabec V. The stability of DNA intrastrand cross-links of antitumor transplatin derivative containing non-bulky methylamine ligands. Journal of Biological Inorganic Chemistry. 2014.
Frýbortová M., Nováková O., Štěpánková J., Novohradský V., Gibson D., Kašpárková J., Brabec V. Activation of trans geometry in bifunctional mononuclear platinum complexes by a non-bulky methylamine ligand. Journal of Inorganic Biochemistry. 2013.
Zhao Y., Woods JA., Farrer NJ., Robinson KS., Prachařová J., Kašpárková J., Nováková O., Li H., Salassa L., Pizarro AM., Clarkson GJ., Song L., Brabec V., Sadler PJ. Diazido mixed-amine platinum(IV) anticancer complexes activatable by visible-light form novel DNA adducts. Chemistry: A European Journal. 2013.
Malina J., Natile G., Brabec V. Spontaneous Translocation of Antitumor Oxaliplatin, its Enantiomeric Analogue, And Cisplatin from One Strand to Another in Double-Helical DNA. Chemistry: A European Journal. 2013.
Muchová T., Quintal SM., Farrell N., Brabec V., Kašpárková J. Antitumor bifunctional dinuclear Pt-II complex BBR3535 forms interduplex DNA cross-links under molecular crowding conditions. Journal of Biological Inorganic Chemistry. 2012.
Suchánková T., Kubíček K., Kašpárková J., Brabec V., Kozelka J. Platinum-DNA interstrand crosslinks: Molecular determinants of bending and unwinding of the double helix. Journal of Inorganic Biochemistry. 2012.
Kisová A., Zerzánková L., Habtemariam A., Sadler PJ., BRABEC V., Kašpárková J. Differences in the cellular response and signaling pathways between cisplatin and monodentate organometallic Ru(II) antitumor complexes containing a terphenyl ligand. Molecular Pharmaceutics. 2011.
Zerzánková L., Suchánková T., Vrána O., Farrell N., Brabec V., Kašpárková J. Conformation and recognition of DNA modified by a new antitumor dinuclear PtII complex resistant to decomposition by sulfur nucleophiles. Biochemical Pharmacology. 2010.
Suchánková T., Vojtíšková M., Reedijk J., Brabec V., Kašpárková J. DNA and glutathione interactions in cell-free media of asymmetric platinum(II) complexes cis- and trans-[PtCl2(isopropylamine)(1-methylimidazole)]. Relations to their different antitumor effects. Journal of Biological Inorganic Chemistry. 2009.
Suchánková T., Vojtíšková M., Reedijk J., Brabec V., Kašpárková J. DNA and glutathione interactions in cell-free media of asymmetric platinum(II) complexes cis- and trans-[PtCl2(isopropylamine)(1-methylimidazole)]: relations to their different antitumor effects. Journal of Biological Inorganic Chemistry. 2009.
Nováková O., Malina J., Kašpárková J., Halámiková A., Bernard V., Intini F., Natile G., Brabec V. Energetics, conformation, and recognition of DNA duplexes modified by methylated analogues of [PtCl(dien)]+. Chem Eur J, 15, 6211-6221. Chemistry: A European Journal. 2009.
Ruhayel R.A.., Moniodis J.J.., Yang X., Kašpárková J., Brabec V., Bernes-Price S., Farrell N. Factors affecting DNA-DNA interstrand cross-links in the antiparallel 3'-3' sense: A comparison with the 5'-5' directional isomer. Chemistry: A European Journal. 2009.
Mašek V., Anzenbacherová E., Machová M., Brabec V., Anzenbacher P. Interaction of antitumor platinum complexes with human liver microsomal cytochromes P450. Anti-cancer Drugs. 2009.
Krause-Heuer A., Brabec V. Studies of the mechanism of action of platinum(II) complexes with potent cytotoxicity in 2 human cancer cells. Journal of Medicinal Chemistry. 2009.
Castellano-Castillo M., Kostrhunová H., Marini V., Kašpárková J., Sadler P., Malinge J., Brabec V. Binding of mismatch repair protein MutS to mispaired DNA adducts of intercalating ruthenium(II) arene complexes. Journal of Biological Inorganic Chemistry. 2008.
Kašpárková J., Marini V., Bursová V., Brabec V. Biophysical Studies on the stability of DNA intrastrand cross-links of transplatin. Biophysical Journal. 2008.
Bugarcic T., Nováková O., Halámiková A., Zerzánková L., Vrána O., Kašpárková J., Habtemariam A., Pardone S., Sadler P., Brabec V. Cytotoxicity, cellular uptake, and DNA interactions of new monodentate ruthenium(II) complexes containing terphenyl arenes. Journal of Medicinal Chemistry. 2008.
Bugarcic T., Habtemariam A., Štěpánková J., Heringová P., Kašpárková J., Deeth J.R.., Johnstone R.D.L., Prescimone A.., Parsons S.., Parkin A.., Brabec V., Sadler P. The contrasting chemistry and cancer cell cytotoxicity of bipyridine and bipyridinediol ruthenium(II) arene complexes. Inorganic Chemistry. 2008.
KAPITOLA V KNIZE
Brabec V., Kašpárková J. Role of DNA repair in antitumor effects of platinum drugs. Metal Complex - DNA Interactions. 2009.
ABSTRAKT
Brabec V., Prachařová J., Kašpárková J., Sadler PJ. Interactions of DNA with a New Platinum(IV) Azide Dipyridine Complex Activated by UVA and Visible Light: Relationship to Toxicity in Tumor Cells. Journal of Biological Inorganic Chemistry. 2014.
Kašpárková J., Mlčoušková J., Brabec V. Light-potentiated Cytotoxicity of Carboplatin in Tumor Cells: Enhanced DNA Binding. Journal of Biological Inorganic Chemistry. 2014.

Uživatel nepovolil zobrazení dat v Portále UP.

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